Baskar Selvaraj

Passionate Postdoctoral Researcher with expertise in HTS/HCS drug screening, neuroprotection, autophagy, inflammation, and antibody drug development. Skilled in experimental design with a keen eye for detail, eager to explore and integrate new technologies to advance drug discovery for proteinopathies. Guided by the scientific dialogue of “from parts to the whole,” a reductionist in training aspiring to become a holist, dedicated to transforming molecular insights into holistic therapeutic innovation.

Best Poster award received for the poster titled"The novel compound DTC1225 activates autophagy via the AMPK-mTORC1-TFEB pathway and reduces hepatic lipid accumulation in a NAFLD mouse model". Division of Medicinal Chemistry. Korean Chemical Society. 10th July, 2025.

KGSP fellowship, global Korea scholarship from NIIED - National Institute for International Education, Ministry of education, Korea 2016 to 2020.

Master's degree fellowship from Ministry of Human Resource Development of India for GATE qualified candidates, July 2010 to May 2012.

Junior research fellowship awarded by Department of Science and Technology of India for a research project under Dr. DebasishDas. Department of Biotechnology, Indian Institute of Technology Guwahati India, August 2012 to July 2014.

• Post Doc Researcher, 04/01/22, 09/30/25, Korea Institute of Science and Technology, South Korea, Department of natural products chemistry, Dr. Jae Wook Lee, HTS/HCS screening of natural products for neuroprotection against glutamate-induced neurotoxicity, EpCAM ADC development for the treatment of colon cancer
• Post Doc Researcher, 08/01/21, 03/31/22, Researcher iPS Bio Co., Ltd, Seongnam-si, Gyeonggi-do, Korea, Prof. Song Ji-hwan, High-throughput drug screening for Huntington's disease using induced pluripotent stem cells
• Junior Research Fellow, 08/01/12, 07/31/14, Indian Institute of Technology Guwahati, India, Department of biotechnology, Dr. Debasish Das, Enhanced lipid content in Chlorella sp. FC2 IITG via high energy irradiation mutagenesis

• Dr. Jae Wook Lee, Principal Research Scientist, Natural Product Chemistry Research Center, Korea Institute of Science and Technology, Gangneung, South Korea, jwlee5@kist.re.kr, +82, 10-64289329
• Dr. Kyungsu Kang, Principal Research Scientist, Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, South Korea, kskang@kist.re.kr, +82, 10-27060469
• Dr. Park Jinsoo, Principal Research Scientist, Natural Product Chemistry Research Center, Korea Institute of Science and Technology, Gangneung, South Korea, jinsoopark@kist.re.kr, +82, 033-650-3509

Note:* Equal Contribution as First Author.

1.NTA Nguyen*, B Selvaraj*,HT Vu, QNS Nguyen, LH Oanh, H Lee, QL Tran, JW Lee. (2025)The Ethanol Extract of Polyscias scutellaria(EEPS) Shows Anti-Inflammatory Signaling Pathway Against LPS-Induced Inflammation in RAW 264.7 Macrophages. Natural Product Communications 20 (3), 1934578X251324006. (SCIE, SSN: 1934-578X, IF:1.5).

2.MS Kim*, B Selvaraj*, HT Yeo, JS Park, JW Lee, JS Park. (2025) Discovery Of 15-deoxynaphthomycins Activating The Antioxidant NRF2-ARE Pathway From Streptomyces Sp. N50 Via Genome Mining, Global Regulator Introduction. Microbial Cell Factories 24 (1), 14. (SCIE, ISSN: 1475-2859, IF:4.5).

3.QNS Nguyen, KY Yoo, TTT Pham, B Selvaraj, HT Vu, TT Le, H Lee. JW Lee. (2024) Neuroprotective Effects of Ethanol Extract Polyscias guilfoylei(EEPG) Against Glutamate Induced Neurotoxicity in HT22 Cells. International Journal of Molecular Sciences 25 (22), 12153. (SCI, ISSN: 1422-0067, IF:4.9).

4.HI Kim, A Veeramanoharan, B Selvaraj, M Olivier, E Lee, JW Lee. (2024) Thiiranes: Intelligent Molecules for S-Persulfidation. Journal of the American Chemical Society 146 (13), 8820-8825. (SCI, ISSN: 0002-7863, IF:14.6)

5.B Selvaraj, DW Kim, KY Yoo, K Park, TTT Tran, JW Lee, H Lee. (2024) Neuroprotective Mechanism Of Corydaline In Glutamate-induced Neurotoxicity In HT22 Cells. International Journal of Oral Biology 49 (1), 10-17. (ISSN: 1226-7155).

6.VD Hong, VT Vu, B Selvaraj, NM Tuyen, NM Khoi, ND Thuan, PT ThuongJW Lee. (2023) Chemical Constituents and Neuroprotective Activity of Hypericum hookerianum. Natural Product Communications 18 (5), 1934578X231164818. (SCIE, ISSN: 1934-578X, IF:1.5).

7.B Selvaraj, SH Lee, NQN Sang, H Lee, JW Lee. (2023) SYnthesisAnd Evaluation Of CardamoninDerivatives As Antiproliferative Agents To Human Cancer Cells. Bulletin of the Korean Chemical Society 44 (3), 208-212. (SCIE, ISSN: 0253-2964, IF:2.3).

8.B Selvaraj, TT Le, DW Kim, BH Jung, KY Yoo, HR Ahn, PT Thuong, JW Lee. (2023) Neuroprotective Effects of Ethanol Extract of Polyscias fruticosa (EEPF) against Glutamate-Mediated Neuronal Toxicity in HT22 Cells. International Journal of Molecular Sciences 24 (4), 3969. (SCI, ISSN: 1422-0067, IF:4.9).

9.EK Jeong*, B Selvaraj*, S Clovis, YJ Son, TH Park, A Veeramanoharan, JW Lee. (2023) Synthesis And Neuroprotective Effects Of H2s-donor-peptide Hybrids On Hippocampal Neuronal Cells. Free Radical Biology and Medicine 194, 316-325. (SCIE, ISSN: 0891-5849, IF:7.3).

10.H Lee, B Selvaraj, JW Lee. (2021) Anticancer Effects Of Seaweed-derived Bioactive Compounds. Applied Sciences 11 (23), 11261 33. (SCIE, ISSN: 2076-3417, IF:2.67).

11.B Selvaraj, DwKim, JsPark, HcKwon, H Lee, Ky Yoo, JwLee. (2021). Neuroprotective Effects Of 2-heptyl-3-hydroxy-4-quinolone In HT22 Mouse Hippocampal Neuronal Cells. Bioorganic & Medicinal Chemistry Letters 49, 128312. (SCIE, ISSN: 0960-894X, IF:2.5).

12.J Kwon, H Hwang, B Selvaraj, JH Lee, W Park, SM Ryu, D Lee, JS Park. (2021) Phenolic Constituents Isolated From Senna Tora Sprouts And Their Neuroprotective Effects Against Glutamate-induced Oxidative Stress In HT22 And R28 Cells. Bioorganic Chemistry 114, 105112. (SCIE, ISSN: 0045-2068, IF:2.97).

13.B Selvaraj, UTT Nguyen, G Huh, DH Nguyen, IK Mok, H Lee, K Kang. (2020) Synthesis And Biological Evaluation Of Chalcone Derivatives As Neuroprotective Agents Against Glutamate-induced HT22 Mouse Hippocampal Neuronal Cell Death. Bioorganic & Medicinal -

Chemistry Letters 30 (22), 127597 7. (SCIE, ISSN: 0960-894X, IF:2.5).    

14.B Selvaraj, DW Kim, G Huh, H Lee, K Kang, JW Lee. (2020) Synthesis And Biological Evaluation Of IsoliquiritigeninDerivatives As A Neuroprotective Agent Against Glutamate Mediated Neurotoxicity In HT22 Cells. Bioorganic & Medicinal Chemistry Letters 30 (8), 127058. (SCIE, ISSN: 0960-894X, IF:2.5).

15. B Selvaraj*,KY Yoo, SH Ko. (2020) Flavonoids As Anti-inflammatory And Neuroprotective Agents. International Journal of Oral Biology 45 (2), 33-41. ISSN: 1226-7155

16.Tan Le, B Selvaraj, JW Lee, K Kang. (2019). Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans. Journal of Visualized Experiments (JoVE), e60419. (SCIE, ISSN: 1940-087X, IF:1.16).

17.AS Aslam, A Fuwad, H Ryu, B Selvaraj, JW Song, DW Kim, SM Kim. (2019) Synthetic Anion Transporters As Endoplasmic Reticulum (ER) Stress Inducers. Organic Letters 21 (19), 7828-7832. (SCI, ISSN: 523-7060, IF:4.9).

18.M Muthuraj*, B Selvaraj*, B Palabhanvi, V Kumar, D Das. (2019) Enhanced Lipid Content In Chlorella Sp. FC2 IITG Via High Energy Irradiation Mutagenesis. Korean Journal of Chemical Engineering 36, 63-70. (SCI, ISSN: 0256-1115, IF:3.0).

HTS/HCS drug screening (Operetta system), Western blot/Immunoblot analysis, immunofluorescence imaging, time-lapse and confocal microscopy, Autophagy and lysosome imaging.

Flow cytometry (Apoptosis, Cell cycle) and cell sorting (FACS), cell toxcicity and cell viability assays (EZ-cytox, cell titer glo, calcein AM). Luciferase assays (CTG, ONE-Glo, HiBiT), Aβ1-42 toxicity assay. NO assay ROS and Calcium influx fluorescence Imaging, DND160 pH imaging, Cell fractionation.

Primary cortical neuron culture from prenatal mouse brain, mouse model dissection and isolation of pre-cortex, hippocampus, liver, blood and heart. Mouse oral feeding and IP injection. 

Mammalian cells gene transfection and stable cell line generation (made 8 stable cell lines during my Ph.D). siRNA gene knock down, DNA/RNA/Plasmid isolations, gene cloning, cDNA synthesis, qPCR, siRNA gene knock down and mammalian vector designing, DNA sequence analysis.

Antibody-drug conjugate analysis, DAR analysis, Cathepsin B assay, pulldown-assay using photo-affinity linkers, drug analysis using HPLC-MS, HIC chromatography, FPLC chromatography.

Software Skills: Nerwork Pharmacology, Cytospace, Discovery Studio, primer design, DNA sequence analysis (ClustalW, Blast, SNP), ImageJ, GraphPad Prism, Mendeley/EndNote, Biorender.