Kunal N. More

Innovative chemist with expertise in the design, structure-activity relationship (SAR), and synthesis of novel small molecule enzyme inhibitors, demonstrating a strong ability to create and optimize synthetic schemes. Proficient in developing chemical markers for cancer detection, utilizing fluorescent probes and PET tracers to enhance diagnostic capabilities. Skilled in extracting, isolating, and synthesizing unique chemical markers from natural sources, contributing to advancements in targeted therapies. Committed to leveraging cutting-edge techniques to drive research and development in the pharmaceutical field.

• Expert practical hands on
• Microwave CEM discover benchmate and Biotage.
• Waters HPLC 2690, ACQUITY UPLC, and Agilent HPLC.
• Micromass Quattro microTM.
• Bruker AVANCE 400 NMR.
• Jeol JNM-AL400 NMR.
• Biotek Synergy H1 microplate reader.

• First prize in “WORKING MODELS IN CHEMISTRY”, One-day exhibition at Vellore Institute of Technology, VIT University, Vellore, TN, India.
• Participation in “WORKSHOP ON INSTRUMENTAL METHODS OF ANALYSIS” at Vellore Institute of Technology, VIT University, Vellore, TN, India.
• Poster presented in 110th, Korean Chemical Society general meeting, BEXCO, Busan, KOREA.
• Poster presented in 111th, Korean Chemical Society general meeting, KINTEX, Goyang, KOREA.
• Poster presented in 114th, Korean Chemical Society general meeting, Kimdaejung Convention Center, Gwangju, KOREA.
• Poster presented in Spring International Convention of the Pharmaceutical Society of Korea, 2014, The K-Hotel, Seoul, Seocho-gu, KOREA.
• Poster presented in Fall International Convention of the Pharmaceutical Society of Korea, 2014, Hotel Hyundai, Gyeongju, Gyeongsangbuk-do, KOREA.
• Poster presented in Spring International Convention of the Pharmaceutical Society of Korea, 2015, OSONG Medical Innovation Foundation C&V Center, Chungcheongbuk-do, KOREA.
• Oral presentation with best poster award in 12th Pharmaceutical Society of Korea workshop of Medicinal chemistry, 2016, Muchangpo Beach Palace, Boryeong, South Chungcheong province, South Korea.
• Oral presentation with award in Fall International Convention of the Pharmaceutical Society of Korea, 2019, Yeosu Expo Convention Center, Yeosu, South Chollanamdo province, South Korea.

• Kunal N. More, Tae-Hwan Lim, Julie Kang, and Dong-Jo Chang. (2021) A Fluorogenic Assay: Analysis of Chemical Modification of Lysine and Arginine to Control Proteolytic Activity of Trypsin, Molecules, 26 (7), 1975, 1-12. (IF= 4.927)
• Julie Kang, Kunal N. More, Ayoung Pyo, Yerim Jung, Dong-Yeon Kim, Dong-Jo Chang. (2021) Bisoprolol-based 18F-PET tracer: Synthesis and preliminary in vivo validation of β1-blocker selectivity for β1-adrenergic receptors in the heart, Bioorganic & Medicinal Chemistry Letter, 36 (127789), 1-5. (IF= 2.823)
• Kunal N. More, Seul-Ki Mun, Julie Kang, Jong-Jin Kim, Sung-Tae Yee, and Dong-Jo Chang. (2021) Molecular design of fluorescent pH sensors based on reduced rhodol by structure-pKa relationship for imaging of lysosome, Dyes and Pigments, 184 (108785), 1-8. (IF= 5.122)
• Kunal N. More, Yong-Jin Lee, Kwang-Jin Kim, Young-Ger Suh, Young-Jin Son, Dong-Jo Chang. (2020) Effect of TRPV1 Antagonist SC0030, a Potent Painkiller, on RANKL-mediated Osteoclast Differentiation Involved in Bone Resorption, Bulletin of the Korean Chemical Society, 41, 488-491. (IF= 1.241)
• Kunal N. More, Jun Young Lee, Jeong-Hoon Park, and Dong-Jo Chang. (2019) 1-Benzyl indazole derivative-based 18F-labeled PET radiotracer: Radiosynthesis and cell uptake study in cancer cells, Journal of Radiopharmaceuticals and Molecular Probes, 5 (1), 36-47.
• Kunal N. More, Tae-Hwan Lim, Julie Kang, Sung-Tae Yee, and Dong-Jo Chang. (2019) Asymmetric and Reduced Xanthene Fluorophores: Synthesis, Photochemical Properties, and Application to Activatable Fluorescent Probes for Detection of Nitroreductase, Molecules, 24 (17), 3206, 1-16. (IF= 4.927)
• Nam-Sook Park, Yu-Kyung Park, Mahesh Ramalingam, Anil Kumar Yadav, Hyo-Rim Choa , Victor Sukbong Hong, Kunal N. More, Jae-Hoon Bae, David Bishop-Bailey, Junko Kano, MasayukiNoguchi, Ik-Soan Jang, Kyung-Bok Lee, Jinho Lee, Jong-Soon Choi, Byeong-Churl Jang. (2018) Meridiani C inhibits the growth of YD-10B human tongue cancer cells through macropinocytosis andthe down-regulation of Dickkopf-related protein-3, Journal of cellular and Molecular Medicine, 22(12), 5833-584614. (IF= 5.295)
• Julie Kang, Jun Young Lee, Īsa Tas, Kunal N More, Hangun Kim, Jeong-Hoon Park, Dong-Jo Chang. (2018) Radiosynthesis, biological evaluation and preliminary microPET study of 18F-labeled 5-resorcinolic triazolone derivative based on ganetespib targeting HSP90, Bioorganic & Medicinal Chemistry Letter, 28 (23-24), 3658-3664. (IF= 2.823)
• Kunal N. More, Victor S. Hong, Ahyeon Lee, Jong sung Park, Shin Kim, Jinho Lee. (2018) Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors. Bioorganic & Medicinal Chemistry Letter, 28 (14), 2513-2517. (IF= 2.823)
• Kunal N. More, Jun Young Lee, Dong-Yeon Kim, Ayoung Pyo, Misun Yun, Hyeon Sik Kim, Hangun Kim, Jeong-Hoon Park, Dong-Jo Chang. (2018) Acetazolamide-based [18F]-PET tracer: In vivo validation of carbonic anhydrase IX as a sole target for imaging of hypoxic tumor. Bioorganic & Medicinal Chemistry Letter, 28(5), 915-921. (IF= 2.823)
• Kunal N. More, Tae-Hwan Lim, So-Young Kim, Julie Kang, Kyung-Soo Inn and Dong-Jo Chang. (2018) Characteristics of new bioreductive fluorescent probes based on the xanthene fluorophore: Detection of nitroreductase and imaging of hypoxic cells. Dyes and Pigments, 151, 245-253. (IF= 5.122)
• Kunal N. More, & Jinho Lee. (2017) Synthesis of (3-(2-Aminopyrimidin-4-yl)-4-hydroxyphenyl) phenyl Methanone Analogues as Inhibitors of Vascular Endothelial Growth Factor Receptor-2 Kinase. Bulletin of the Korean Chemical Society, 38(1), 70-77. (IF= 1.241)
• Kunal N. More, Hyo Weon Jang, Victor S. Hong, Jinho Lee. (2014) Pim kinase inhibitory and antiproliferative activity of a novel series of meridiani C derivatives. Bioorganic & Medicinal Chemistry Letters, 24(11), 2424-2428. (IF= 2.823)
• Jinho Lee, Kunal N More, Seun-Ah Yang, Victor S. Hong. (2014) 3, 5-Bis (aminopyrimidinyl) indole Derivatives: Synthesis and Evaluation of Pim Kinase Inhibitory Activities. Bulletin of the Korean Chemical Society, 35(7), 2123-2129. (IF= 1.241)
• Mi-Hee Yu, Jun-Hyeok Choi, In-Gyeong Chae, Hyo-Gwon Im, Seun-Ah Yang, Kunal More, In-Seon Lee, Jinho Lee. (2013). Suppression of LPS-induced inflammatory activities by Rosmarinus officinalis L. Food Chemistry, 136(2), 1047-1054. (IF= 9.231)
• Chinar Pathak, S. Karthikeyan, Kunal More, & V. Vijaya Kumar (2007) Screening of antimicrobial activity of 2, 6, 8-tetraaryl-3, 7-diazabicyclo [3.3.1] nonan-9-one and its derivatives. Indian Journal of Heterocyclic Chemistry, 16(3), 295-296. (IF= 0.339)
• Dong-Jo Chang, Sung-Tae Yee, Kunal N. More, Julie Kang. Novel rhodol derivatives, fluorescent probes comprising same, and fluorescent sensors (신규한 로돌 유도체, 이를 포함하는 형광 프로브,및 형광 센서) (Korea Patents, Application Number 10-2020-0070570).