Sung-Jin Choi
3D Structure Determination, Computer-Aided Drug/Antibody Discovery, Exosomes
Summary
Resourceful Project Manager with 7 months of expertise in engineering of nanoparticles including exosomes and liposmes. Designed and Monitors projects by adhering to production schedule, managing experimental team, identifying problems and providing targeted solutions.
Providing knowledge of structural biology and chemistry for graph deep learning-based epitope predictor development with direction.
Experts in experimentally determining 3D structures such as proteins and nucleic acids.
Developing docking programs using PyRosetta.
Antibody design using PyRosetta and Rosetta programs.
Discovery and lead optimization of chemicals using docking programs and molecular dynamics simulation.
Overview
5
5
years of professional experience
17
17
years of post-secondary education
Work History
Project Manager
SURGINEX
Seoul
04.2022 - Current
- Designed and achieved exosome engineering using genetic engineering for cancer therapy.
- Designed and performed liposome engineering using tag-conjugation method for cancer therapy.
- Wrote a grant for CEO entitled in "2022 The Catholic Univ. of Korea Seoul St. Mary's Hospital Bio Core Facility Establishment Project" successfully selected.
- Developed antibody-antigen docking program after epitope prediction using PyRosetta and python.
- Managed 11 grants in Catholic Central Laboratory of Surgery, Institute of Biomedical Industry, College of Medicine, the Catholic University of Korea, Seoul.
- Involved in molecular dynamics (MD) simulation automation.
- Contributed to and actively participated in Graph Deep Learning-based epitope prediction model.
- Writing a paper regarding advanced AI-based epitope prediction.
- Leveraged interpersonal and communication skills to manage the exosome engineering projects, grant-related projects, and liposome engineering projects.
Postdoctoral Research Fellow
DGIST
Deagu
08.2020 - 04.2022
- Contributed to and actively participated in NK cell-derived exosome project, T cell/Jurkat-derived exsome project for cancer therapy.
- Coauthor of a paper entitled in "Novel antitumor therapeutic strategy using CD4+ T cell-derived extracellular vesicles" published in Biomaterials (2022).
- First author of a paper entitled in "Immune cell-derived sEVs in cancer treatment" published in BMB Rep. (2021).
- Coauthor of a paper entitled in "Novel immunotherapeutic approach using T-cell derived IL2-linked extracellular vesicles" under submission.
- Coauthor of a paper entitled in "IL2 induces anticancer immune response by reducing exosomal PD-L1 in cancer cells" under submission.
- Coauthor of a patent (patent #: 1-1-2020-1151169-11) entitled in "Composition for treating cancer diseases comprising extracellular vesicles derived from natural killer cells with surface expression of cytokines and antibodies"
- Improved the potency of agonist antibody for obesity treatment via computer-aided approach using Rosetta programs, and protein docking programs (HADDOCK, SnugDock, HDOCK et cetera).
- Discovered the chemical compound candidates for obesity treatment using chemical docking programs, ZINC20, chemical toolkits, and so on.
- Heat-optimization of chemical compounds using molecular dynamics (MD) simulation.
- Successful recipient of National Research Foundation of Korea (NRF)'s grant of research program for cultivating follow-up generation of science and engineering for 3 years from Sep. 1th, 2020.
Postdoctoral Research Fellow
National Institute of Health, National Cancer Institute
Bethesda
05.2017 - 07.2020
- Contributed to and actively participated in multi-disciplinary approaches on centriole-assembly and PLK4 inhibitor.
- Determination of crystal structure of the chimeric protein of Cep57(63-93)-GGGSE-Cep63(16-40) at 2.7 A using single-wavelength anomalous diffraction (SAD).
- Determination of crystal structure of the Cep63(8-43):Cep57(63-115) complex at 3.4 A using molecular replacement (MR).
- Determination of crystal structure of the Polo-like kinase 1 (371-603):citrate complex at 1.7 A using MR.
- Determination of crystal structure of the Polo-like kinase 1 (371-603):malonate complex at 1.9 A using MR.
- Successful recipient of the Korea Health Industry Development Institute (KHIDI)'s grant for post-doctoral training course in the Unitied States (National Institutes of Health) under the Korea Visting Scientist Training Award (KVSTA) program for 2 years starting December 1st, 2017.
- Developed unique research into [Area of study].
Education
Ph.D. - Biochemistry
Pohang University of Science And Technology
Pohang 09.2009 - 02.2017
Master of Science - Structural Biology Program
Pohang University of Science And Technology
Pohang 03.2007 - 08.2009
Bachelor of Science - Biology, And Chemistry
Jeju National University
Jeju 03.2002 - 02.2006
High School Diploma -
Jeju Science High School
Jeju 03.1999 - 09.2002
Skills
Advanced problem solving
undefinedTimeline
Project Manager
SURGINEX
04.2022 - Current
Postdoctoral Research Fellow
DGIST
08.2020 - 04.2022
Postdoctoral Research Fellow
National Institute of Health, National Cancer Institute
05.2017 - 07.2020
Ph.D. - Biochemistry
Pohang University of Science And Technology
09.2009 - 02.2017
Master of Science - Structural Biology Program
Pohang University of Science And Technology
03.2007 - 08.2009
Bachelor of Science - Biology, And Chemistry
Jeju National University
03.2002 - 02.2006
High School Diploma -
Jeju Science High School
03.1999 - 09.2002
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