I conducted research during my doctoral degree on the mechanisms of nerve regeneration following peripheral nervous system injury models. Subsequently, I investigated the use of several drugs to inhibit degeneration and reduce pain during the process of nerve degeneration. Unlike nerve cells in the central nervous system, which are relatively compact, those in the peripheral nervous system consist of very long single cells, with damage at the terminals reaching the cell bodies and undergoing regeneration a unique structure. Therefore, studying these regeneration mechanisms is crucial not only for understanding peripheral nerve regeneration but also for investigating different regeneration mechanisms in the central nervous system in the future.
I have technique the skills to conduct research on cell regeneration and degeneration in the peripheral nervous system, and I am also interested in exploring mechanisms of regeneration in the central nervous system.
Thank you for your attention.
I conducted research on the mechanisms of nerve regeneration following peripheral nerve injury models, and subsequently explored the use of drugs involved in the process of nerve degeneration to inhibit degeneration and reduce pain.
Teaching class and preparing experiments.
Research Methodologies
1. Kim HR*, Lee HJ, Jeon Y , et al. Targeting SARM1 improves autophagic stress-induced axonal neuropathy. Autophagy. Published online 2023. doi:10.1080/15548627.2023.2244861
2. Jeon Y *, Shin YK, Kim H, et al. βPix Guanine Nucleotide Exchange Factor Regulates Regeneration of Injured Peripheral Axons. Int J Mol Sci. 2023;24(18):1-17. doi:10.3390/ijms241814357
3. Jeon Y *, Shin JE*, Kwon M, Cho E, Cavalli V, Cho Y. In Vivo Gene Delivery of STC2 Promotes Axon Regeneration in Sciatic Nerves. Mol Neurobiol. 2021;58(2):750-760. doi:10.1007/s12035-020-02155-2
4. Kwon Y*, Jeon YW , Kwon M, Cho Y, Park D, Shin JE. βPix-d promotes tubulin acetylation and neurite outgrowth through a PAK/Stathmin1 signaling pathway. PLoS One. 2020;15(4):1-23. doi:10.1371/journal.pone.0230814
5. Lee J*, Shin JE*, Lee B, Jeon Y et al. The stem cell marker Prom1 promotes axon regeneration by down-regulating cholesterol synthesis via Smad signaling. Proc Natl Acad Sci U S A. 2020;117(27):15955-15966. doi:10.1073/pnas.1920829117