A well-rounded and skilled Bioorganic chemist across multiple disciplines of chemistry, including Nucleic acids chemistry, synthetic, analytical, phytochemistry, and computational, with demonstrated a keen interest in working at multiple scientific interfaces in the research focuses:
Ph.D. Thesis: 2’-O-Methyl-8-methylguanosine as a Z-Form Stabilizer for Structural and Functional Study of Z- RNA and Z-DNA. Department of medicine, Division of Chemistry. Miyazaki University, Japan. Advisor: Prof. Xu Yan.
M.Sc. Thesis: The variable light intensity on biofilm development and localized corrosion of UNS S30400 stainless steel in seawater. Project was done at Biochemical department, Central Science and Industrial Research( CSIR-CECRI) - central electrochemical institute of India, Mandapam, India.
July 2016 – Mar 2018: Otsuka Toshimi fellowship
April 2015 – Mar 2016: JASCO fellowship
July 2016 – RASA’s Research Grant
Dec 2013 – May 2014: M.Sc. project
Central Electro Chemical Research Institute, Mandapam, India.
Research topic: The variable light intensity on biofilm development and localized corrosion of UNS S30400 stainless steel in seawater.
Experimental Techniques:
Bioorganic Chemistry:
Microbial Techniques:
Other Techniques:
Computational Biology:
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Memberships : The Chemical Society of Japan (CSJ)
The Chemical Society of South Korea (CSSK)
Reviewer : Chemical and Biomolecular Engineering (Journal)
1) Thananjeyan Balasubramaniyam , Takumi Ishizuka , Chao-Da Xiao , Hong-Liang Bao and Yan Xu “ 2’-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA ” Molecules.2018 Oct; 23(10): 2572.
2) Thananjeyan Balasubramaniyam , Takumi Ishizuka , and Yan Xu “Stability and properties of Z-DNA containing artificial nucleobase 2'-O-methyl-8-methyl guanosine”. Bioorg Med Chem. 2018 Dec 6. pii: S0968-0896(18)31790-5.
3) Thananjeyan Balasubramaniyam , Kwnag-Im Oh, Ho-Seong Jin , Hye-Bin Ahn , Byeong-Seon Kim , Joon-Hwa Lee “Non-Canonical Helical Structure of Nucleic Acids Containing Base-Modified Nucleotides“ PMC8430589 DOI: 10.3390/ijms22179552.
4) Thananjeyan Balasubramaniyam , Byeong-Seon Kim ,Badvel Pallavi ,Ho-Seong Jin ,Sung Kuk Kim and Joon-Hwa Lee 1 “A Green Chemical Approach for Iodination of Pyrimidine Derivatives by Mechanical Grinding under Solvent-Free “ DOI: https://doi.org/10.3390/molecules27196386.
5) Thananjeyan Balasubramaniyam , Shailima Rampogu, Joon-Hwa Lee “Phytotherapeutic applications of alkaloids in treating breast cancer .DOI: 10.1016/j.biopha.2022.113760.
6) Thananjeyan Balasubramaniyam , Seo-Ree Choi , Vinod Kumar Nathan , Abhishikta Basu , and Joon-Hwa Lee “A new perspective at the metabolites and bioactive substances that are derived from fungal sources “ The American Journal of Chinese Medicine.
7) Shailima Rampogu,Thananjeyan Balasubramaniyam,and Joon-Hwa Lee2,“ Curcumin Chalcone Derivatives database (CCDD): A Python Framework for Natural Compound Derivatives Database. DOI:10.7717/peerj.15885 Peer J .
8) Kwang-Im Oh; Ho-Seong Jin; Thananjeyan Balasubramaniyam; Ji-Yeon Shin; Seo-Ree Choi; Young Jun Seo; Byeong-Seon Kim; Yeo-Jin Seo; Seung-Ryong Kwon; Nak-Kyoon Kim “Entropy-driven conformational transition of flexible Z-DNA to a novel non-B helix by double-methylated guanosine.DOI: 10.1016/j.biopha.2022.113760. Journal of Molecular Liquids.
1. Anti-inflammatory therapy involving polysaccharides: a look into the future.
Thananjeyan Balasubramaniyam , Seo-Ree Choi , Vinod Kumar Nathan , Abhishikta Basu , and Joon-Hwa Lee. (submitted to Carbohydrate Polymers)
2. Triple helix-interacting proteins and role in therapeutics.
Thananjeyan Balasubramaniyam , Shailima Rampogu , and Joon-Hwa Lee.
3. Virus and Corona virus Modified nucleobase fusion inhibitor identified by Pre-trained Deep Learning-based Approaches .
Thananjeyan Balasubramaniyam, and Joon-Hwa Lee.
4. Investigating the COVID-19 therapeutic potential of marine-derived bioactive compounds.
Thananjeyan Balasubramaniyam, and Joon-Hwa Lee. .
1. NMR investigations of protein structure and dynamics, molecular docking, and molecular dynamics constitute a novel approach to characterizing Z-forms protein-ligand complexes.
Thananjeyan Balasubramaniyam, and Joon-Hwa Lee.
2. A novel database of Modified nucleobases : Therapeutically approach.
Thananjeyan Balasubramaniyam , Shailima Rampogu , and Joon-Hwa Lee.
3. cheilocostus speciosus (j. koenig) leaf extract (Biomolecules) as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Monkey Pox.
Thananjeyan Balasubramaniyam, and Joon-Hwa Lee.
4. A Novel Modified nucleobase Inhibitor of the Mycobacterium tuberculosis.
Thananjeyan Balasubramaniyam, and Joon-Hwa Lee.
5. An influenza A hemagglutinin Modified nucleobase fusion inhibitor identified by a new high-throughput fluorescence polarization screen.
Thananjeyan Balasubramaniyam, and Joon-Hwa Lee.
1) Prof. Dr. Joon-Hwa Lee, Ph.D.,
Professor, Department of Chemistry,Dean, College of Natural Science Gyeongsang National University
501, Jinju Blvd
Jinju, Gyeongnam 52828
Republic of Korea
E-mail: joonhwa@gnu.ac.kr
Phone: +82-55-772-1490
2) Prof. Dr. Xu Yan, Ph.D., Professor, Division of Chemistry, Department of Medical Sciences,
Tel. : +081-0985-85-0993; E-mail: xuyan@med.miyazaki-u.ac.jp
Web : http://www.miyazaki-med.ac.jp/MMCCHEM/index_e_link_e.html
3) Dr. Takumi Ishizuka, Ph.D.., Assistant Professor, Department of Anatomy, Histochemistry and Cell Biology,
Tel. : +081-0985-85-0993; E-mail: tishizuka@med.miyazaki-u.ac.jp
Web : http://www.miyazaki-med.ac.jp/MMCCHEM/index_e_link_e.html