Na-Young Ha (Ph.D)

My research aims to understand the pathogenesis and host immune response to vector-borne disease and emerging infectious disease, including scrub typhus, SFTS (Severe Fever with Thrombocytopenia Syndrome) and respiratory coronaviruses such as SARS-CoV-2. Other areas of interest include identification of novel biomarkers and effective vaccine antigens against infectious disease.

• Lecturer (03/2015 – 02/2017)

Daejeon Health Institute of Technology College (Republic of Korea)

Dep. Clinical Laboratory Science

Lecture: General Microbiology, General Microbiology experiments

(6 hours / week)

임상병리사 (Medical Technologist, No.39072)

1. 쯔쯔가무시 균 특이 항체를 검출하기 위한 조성물 및 키트

(국내, 등록특허, 10-1419791) , 발명자

2. 오리엔티아 쯔쯔가무시균의 혈청형의 동정 방법 및 그 키트

(국내, 등록특허, 10-1648922), 발명자

3. 산화아연 결합 펩티드 서열, 이를 포함하는 복합체, 및 상기 복합체를 포함하는 약학 조성물

(국내, 등록특허, 10-2001289), 발명자

4. 오리엔티아 쯔쯔가무시 균의 TSA56 항원의 에피톱 항원 및 그 용도

(국내, 등록특허, 10-2027816), 발명자

5. 오리엔티아 쯔쯔가무시 균의 신규 재조합 단백질 항원 및 이를 이용한 백신 조성물

(국내, 등록특허, 10-2027809), 발명자

6. 오리엔티아 쯔쯔가무시 균의 신규 재조합 단백질 항원 및 이를 이용한 백신 조성물

(국내, 등록특허, 10-2027817), 발명자

7. 오리엔티아 쯔쯔가무시 균의 신규 재조합 단백질 항원 및 이를 이용한 백신 조성물

(국내, 출원특허, 10-2019-0055172), 발명자

8. RECOMBINANT PROTEIN ANTIGEN OF ORIENTIA TSUTSUGAMUSHI AND VACCINE COMPOSITION USING THE SAME

(국외, 등록특허, US 10,961,284 B2 20210330 20180618 ), 발명자

• 이공분야 기초연구사업 (신진연구자 지원사업, 한국연구재단), 연구책임자

과제번호 : 2020R1C1C1014224

과제명 : 쯔쯔가무시균 유전형에 따른 선천면역 차이 분석 및 이로인한 기억면역 변화 기전 연구

( 2020.03 - 2022.03, 8,000만원(직접비)/년)

• 이공분야 기초연구사업 (중견연구 지원사업, 한국연구재단), 연구책임자

과제번호 : 2022R1A2C1010528

과제명 : 단일세포 멀티오믹스를 이용한 쯔쯔가무시병 병인기전 연구

( 2022.03 - 2026.02, 96,000만원(직접)/년)

11 First-author (Underlined), 1 Correspondence(**), 11 collaboration

25. (Under peer-review, mBio)

Yen Thi Hai Nguyen, Chaewon Kim, Hong-Il Kim, Yuri Kim, Na-Young Ha**, Nam-Hyuk Cho

Alternative splicing variants mixed lineage leukemia 5, a novel cellular receptor for Orientia tsutsugamushi

24. Dong-Min Kim , Yuri Kim, Jun-Won Seo , Jooyeon Lee , Uni Park , Na-Young Ha , Jaemoon Koh , Hyoree Park , Jae-Won Lee, Hyo-Jin Ro , Na Ra Yun , Da Young Kim , Sung Ho Yoon , Yong Sub Na , Do Sik Moon , Sung-Chul Lim , Choon-Mee Kim , Kyeongseok Jeon , Jun-Gu Kang , Na-Yoon Jang , Hyeongseok Jeong , Jungok Kim , Shinhyea Cheon , Kyung Mok Sohn , Jae Youg Moon , Sungmin Kym , Seung Ro Han, Myung-Shin Lee, Hyun-Je Kim , Woong-Yang Park , Ji-Yeob Choi, Hyun-Woo Shin , Hye-Young Kim , Chung-Hyun Cho, Yoon Kyung Jeon , Yeon-Sook Kim, Nam-Hyuk Cho

Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19. Cell Rep. 2021 Oct 5;37(1):109798.

23. Yuri Kim , Shinhyea Cheon ,

Jeong , Uni Park , Na-Young Ha , Jooyeon Lee , Kyung Mok Sohn , Yeon-Sook Kim , Nam-Hyuk Cho

Differential Association of Viral Dynamics With Disease Severity Depending on Patients' Age Group in COVID-19. Front Microbiol. 2021 Jul 23;12:712260

22. Yen Thi Hai Nguyen , Chaewon Kim, Yuri Kim , Kyeongseok Jeon ,Hong-Il Kim , Na-Young Ha **, Nam-Hyuk Cho

The Orientia tsutsugamushi ScaB Autotransporter Protein Is Required for Adhesion and Invasion of Mammalian Cells.

Front Microbiol. 2021 Feb 4;12:626298.

21. Aye Marlar Win, Yen Thi Hai Nguyen, Yuri Kim, Na-Young Ha, Jun-Gu Kang, Hongil Kim, Bo San, Okkar Kyaw, Wah Win Htike, Dong-Ok Choi, Keun-Hwa Lee, Nam-Hyuk Cho

Genotypic heterogenecity of Orientia tsutsugamushi in scrub typhus patients and thrombocytopenia syndrome co-infection, Myanmar.

Emerg Infect Dis. 2020 Aug; 26(8): 1878–1881

20. Ha NY, Kin HI, Kim G, Min CK, Kim Y, Yen NTH, Choi MS, Cho NH

Immunization with a recombinant antigen composed of conserved blocks from TSA56 provides broad genotype protection against scrub typhus. Emerg Microbes Infect.2019;8(1):946-958

19. Keun-Dol Yook, Nayoung Ha

Effect of Scutellaria scordifolia Fisch.ex Schrank Extracts on Biofilm formation and Activation of Klebsiella pnemoniae.

Korean J Clin Lab Sci.2018;50(4):438-443(100.5)

18. Chan-Ki Min, Hong-II Kim, Na-Young Ha, Yuri Kim, Eun-Kyung Kwon, Nguyen Thi Hai Yen, Je-In Youn, Yoon Kyung Jeon, Kyung-Soo Inn, Myung-Sik Choi and Nam-Hyuk Cho

A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses.

Front. Immunol. 9:2022. doi: 10.3389/fimmu.2018.02022(24)

17. Chisong Lee, Hongil Kim, Suyong Kim, Shayan F. Lahiji, Na-Young Ha, Huisuk Yang, Geonwoo Kang, Hai Yen Thi Nguyen, Yuri Kim, Myung-Sik Choi, Nam-Hyuk Cho,* and Hyungil Jung.

Comparative Study of Two Droplet-Based Dissolving Microneedle Fabrication Methods for Skin Vaccination.

Adv. Healthcare Mater. 2018, 1701381(24)

16. Na-Young Ha, Yuri Kim, Chan-Ki Min, Hong-Il Kim, Nguyen Thi Hai Yen, Myung-Sik Choi, Jae-Seung Kang, Yeon-Sook Kim and Nam-Hyuk Cho. Longevity of antibody and T-cell responses against outer membrane antigens of Orientia tsutsugamushi in scrub typhus patients.

Emerging Microbes & Infections (2017) 6, e116; doi:10.1038/emi.2017.106(60)

15. Gwanghun Kim, Na-Young Ha, Chan-Ki Min, Hong-Il Kim, Nguyen Thi Hai Yen, Keun-Hwa Lee , Inbo Oh, Jae-Seung Kang, Myung-Sik Choi, Ik-Sang Kim, Nam-Hyuk Cho.

Diversification of Orientia tsutsugamushi genotypes by intragenic recombination and their potential expansion in endemic areas

PLoS Negl Trop Dis. 2017 Mar 1;11(3):e0005408.(24)(51)

14. Na-Young Ha, Gwanghun Kim, Nam-Hyuk Cho

Book : Rickettsiales (Publisher : Springer, Editor : Sunil Thomas, 2016)

Chapter 17. Epidermiological trends of scrub typhus : Global incidence and vector distribution

13. Jong-Hun Ha, Dong-Hae Lee, Jin-Sik Park, Oh Hyun Cho, Dong-Hoon Kim, Na-Young Ha, Nam-Hyuck Cho, Kyu Jam Hwang, Yong-Gon Cho, Hye-Soo Lee, Won Kil Lee, Yoo Chul Lee, Myung-Je Cho, Woo-Kon Lee, Min-Kyoung Shin

Isolation and Genetic Characterization of Orientia tsutsugamushi from Scrub Typhus Patients in Gyeongsangnam-do, Korea

J.Bacteriology and Virology 2016. Vol. 46(12)

12. Ha NY, Shin HM, Sharma P, Cho HA, Min CK, Kim HI, Yen NTH, Kim IS, Choi MS, Kim YK, Cho NH.

Generation of Protective Immunity Against Orientia Tsutsugamushi infection by Immunization with Zinc Oxide Nanoparticle Combined with ScaA Antigen

J Nanobiotechnol (2016) 14:76 DOI 10.1186/s12951-016-0229-2 (51)

11. Min CK, Cheon SH, Ha NY, Sohn KM, Kim Yuri, Aigerim A, Shin HM, Choi JY, Inn KS, Kim JH, Moon JY, Choi MS, Cho NH, Kim YS.

Comparative and Kinetic Analysis of Viral Shedding and Immunological Responses in MERS Patients Representing Abroad Spectrum of Disease Severity

Scientific Reports.2016.May 05; DOI: 10.1038/srep25359(39)

10. Kim Yuri, Cheon SH, Min CK, Sohn KM, Kang YJ, Cha YJ, Kang JI, Han SK, Ha NY, Kim GH, Aigerim A, Shin HM, Choi MS, Kim SG, Cho HS, Kim YS, Cho NH.

Spread of Mutant Middle East Respiratory Syndrome Coronavirus with Reduced Affinity to Human CD26 during the South Korean Outbreak mBio.2016.March 1.Volume 7 Issue 2; e00019-16(18)

9. S Bang, CK Min, NY Ha, MS Choi, IS Kim, YS Kim.

Inhibition of eukaryotic translation by tetratricopeptide-repeat proteins of Orientia tsutsugamushi

Journal of Microbiology (2016) Vol. 54, No. 2, pp. 136–144 DOI 10.1007/s12275-016-5599-5(26)

8. Park SW, Ha NY, Ryu BY, Bang JH, Song HY, Kim YR, Kim GH, Oh MD, Cho NH, Lee JK.

Urbanization of Scrub typhus disease in South korea

PLoS Negl Trop Dis. 2015 May 22;9(5):e0003814. (54)

7. Ha NY, Sharma P, Kim G, Kim Y, Min CK, Choi MS, Kim IS, Cho NH.

Immunization with an Autotransporter Protein of Orientia tsutsugamushi Provides Protective Immunity against Scrub Typhus

PLoS Negl Trop Dis. 2015 Mar 13;9(3):e0003585.(66)

6. Min CK, Kwon YJ, Ha NY, Cho BA, Kim JM, Kwon EK, Kim YS, Choi MS, Kim IS, Cho NH.

Multiple Orientia tsutsugamushi ankyrin repeat proteins interact with SCF1 ubiquitin ligase complex and eukaryotic elongation factor 1a

PLOS ONE. 2014 Aug 28; 9(8):e105652.

5. Ha NY, Choi MS, Cho NH.

Molecular Characterization of sca Genes Found in Orientia tsutsugamushi Genome

J. Bacteriology and Virology 2013. Vol. 43, No. 2 p.155 – 158

4. Ko Y, Choi JH, Ha NY, Kim IS, Cho NH, Choi MS.

Active Escape of Orientia tsutsugamushi from Cellular Autophagy

Infect Immun. 2013 Feb;81(2):552-559.

3. Choi JH, Cheong TC, Ha NY, Ko Y, Cho CH, Jeon JH, So I, Kim IK, Choi MS, Kim IS, Cho NH.

Orientia tsutsugamushi Subverts Dendritic Cell Functions by Escaping from Autophagy and Impairing Their Migration

PLoS Negl Trop Dis. 2013 Jan;7(1):e1981.

2. Ha NY, Kim Y, Choi JH, Choi MS, Kim IS, Kim YS, Cho NH

Detection of antibodies against Orientia tsutsugamushi Sca proteins in scrub typhus patients and genetic variation of sca genes of different strains Clin Vaccine Immunol. 2012 Sep;19(9):1442-1451.

1. Ha NY, Cho NH, Kim YS, Choi MS, Kim IS.

An Autotransporter Protein from Orientia tsutsugamushi Mediates Adherence to Nonphagocytic

Host Cells. Infect Immun. 2011 Apr;79(4):1718-27.

• Chaewon Kim, Yuri Kim, Yen Thi Hai Nguyen, Hongil Kim, Na-Young Ha and Nam-Hyuk Cho

Comprehensive immune cell profiling in different genotypes of Orinentia tsutsugamushi infections (Co-corresponding author)

• Chaewon Kim, Yuri Kim, Yen Thi Hai Nguyen, Hongil Kim, Na-Young Ha and Nam-Hyuk Cho

Comparative virulence of different strains of Orinentia tsutsugamushi in non-human primate model (Co-corresponding author)

• Na-Young Ha, Shin-Hye Cheon, Hyeongseok Jeong and Yeon-Sook Kim

Efficacy of COVID-19 vaccine in HIV-1 patients (Co-First author)